Pipeline
Indication
Targeted Subgroup
Rationale
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Non-alcoholic Steatohepatitis (NASH)
Obese NASH patients with T2D
Normalizes hepatic central nuclear factor HNF4α, which in multiple models, prevents liver failure; Prevents increase in fibrosis in multiple NASH models.
Type 2 diabetes (T2M)
T2M requiring insulin
In an animal model, eliminates fatty tissue inflammation after only 7 days of oral treatment
Peripheral artery disease (PAD)
Claudication – Impaired walking distance due to increasing leg pain due to impaired blood flow.
Improves multiple factors of endothelial dysfunction associated with claudication.
Critical limb ischemia with diabetic foot infection
Expected to reduce need for amputation by rapidly improving factors associated with disease progression. Proven wound healing properties in wound model. Improves multiple drivers of endothelial dysfunction. Rapidly improves glycemic control.
Coronary artery disease (CAD)
Stable CAD
Prevent progression to heart attacks and complications of atherosclerosis, by improving multiple upstream drivers of disease.
COVID-19
Reduces risk of severe disease
Myocarditis post COVID-19 vaccination
Myocarditis post COVID-19 vaccination
Model of myocarditis post-vaccination shows influx of macrophages into heart. DBI-500 can transiently impede macrophage function with adverse effects on hematology.
Long COVID
In NASH and T2D and obesity, the parameters associated with long COVID are reduced.